Causes of factor X deficiency
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There are 2 known causes of factor X deficiency:
Inherited Factor X Deficiency
Factor X deficiency may be caused by a defect in the factor X gene that is passed down from parents to their children. To have inherited factor X deficiency, a person must receive a defective factor X gene from both parents.1,2
Inherited factor X deficiency affects approximately 1 in every 500,000 people.2
Acquired Factor X Deficiency
Factor X deficiency also may be caused by a medical condition or use of certain medicines. Acquired factor X deficiency is more common than inherited factor X deficiency, and may be caused by1,2:
- Vitamin K deficiency—the body needs vitamin K in order to make coagulation factors
- Severe liver disease—vitamin K is made in the liver
- Use of anticoagulant medicines (eg, warfarin)—these medicines help prevent blood clotting
- Amyloidosis—abnormal buildup of a protein called amyloid in various organs of the body
- National Hemophilia Foundation. Factor X. https://www.hemophilia.org/Bleeding-Disorders/Types-of-Bleeding-Disorders/Other-Factor-Deficiencies/Factor-X. Accessed January 6, 2015.
- MedlinePlus Medical Encyclopedia. Factor X deficiency. http://www.nlm.nih.gov/medlineplus/ency/article/000553.htm. Accessed January 6, 2015.